Biomedical Research, Science, & Technology

March-in authority allows the federal government to grant licenses on privately owned patents for inventions developed with federal funding provided certain statutory requirements are met. It was designed to ensure that the benefits of the American taxpayers’ investment in research and development are reasonably accessible to the public.

In this Report, we matched a sample of Part B drugs and biological products that had price changes between January 2011 and October 2023 with the FDA’s January 2023 list of drug shortages database. Then we analyzed price changes that occurred before and after the shortage, overall and by select drug characteristics of interest.

IntroductionMeans-tested benefits are designed to support basic needs such as food, health insurance, and child care for households with low incomes. When considering whether to take a new job opportunity that will increase their income, recipients of these benefits may be forced to consider trade-offs. For example:

This project explored how workers with low incomes who receive federal benefits weigh factors including marginal tax rates, benefit loss, ease of resuming benefits once lost, and job instability when deciding whether to accept an earnings increase.

Infographic: Earnings, Benefit Loss, and Job Instability: What Do People Receiving TANF Consider When Offered a Higher-Paying Job?Related Products:

The pipeline and commercial market for novel antimicrobial drugs is insufficient to address current and future patient needs or mitigate the loss of effective treatments as antimicrobial resistance spreads. The U.S. Government implements a range of efforts to ensure sustainable availability of antimicrobial treatments, supporting research, product development, and appropriate use.

This report outlines the major issues faced by the U.S. health care workforce. It addresses medical, dental and behavioral health components of the workforce as well as direct care workers. The report also describes opportunities for progress to address these issues and existing activities supported by the Department to address these issues.

Rare cancer clinical trials appear to enroll less diverse participants than clinical trials more broadly and therefore may require additional considerations or unique solutions to diversify participant recruitment. These differences persisted within both NIH and non-NIH funded trials.

The cost of bringing a medical product to the U.S. market has been increasing and clinical trials constitute a large portion of these costs. In drug development, the clinical phase lasts an average of around 95 months compared to 31 months for the non-clinical phase and accounts for 69 percent of overall R&D costs (DiMasi, et al., 2016).

This series of five case studies describe evidence-based, innovative, and exemplary practices that support positive mental health for children. The case studies in five organizations highlight key elements of prevention and promotion efforts in early childhood mental health, as well as the contextual factors that support implementation.Available Reports: